Busujima (Kanji: 毒島, 毒嶋, 毒嶌) is a Japanese surname.
Notable people with the surname include:
Hideyuki Busujima (born 1952/1953), Japanese billionaire businessman, son of Kunio Kunio Busujima (1925–2016), Japanese billionaire businessman
Fictional characters with the surname include:
Hanaka Busujima, a character in the manga and anime series Buso Renkin Miku Busujima, a character in the manga, video game, and anime series Lucky Star Saeko Busujima, a character in the manga and anime series Highschool of the Dead