Isabella of Spain or Isabel of Spain may refer to:

Isabella I of Castile (1451–1504), queen regnant Isabella II of Spain (1830–1904), queen regnant Isabella of Austria (1501–1526), Spanish infanta, queen consort of Denmark-Norway Isabella Clara Eugenia (1566–1633), Spanish infanta, archduchess of the Spanish Netherlands María Isabella of Spain (1789–1848), Spanish infanta, queen consort of the Kingdom of the Two Sicilies Infanta Isabel, Countess of Girgenti, Princess of Asturias (1851-1931), Spanish infanta

See also Isabella, Princess of Asturias (disambiguation) Isabella of Castile (disambiguation)