Santiago López may refer to:
Footballers Santiago López (footballer, born 1982), Uruguayan forward for Villa Española Santiago López (footballer, born 1989), Argentine left-back for Berazategui Santiago López (footballer, born 1991), Uruguayan former midfielder Santiago López (footballer, born 1992), Mexican former midfielder Santiago López (footballer, born August 1997), Argentine centre-back Santiago López (footballer, born December 1997), Argentine midfielder for Gimnasia Mendoza Santiago López (soccer, born 2005), Canadian forward for UNAM Santiago López (footballer, born 2006), Argentine winger for Independiente
Other people Santiago López Becerra (born 1949), Mexican politician Santiago López de Medrano (born 1942), Mexican mathematician Santiago López de Rego y Labarta (1869–1941), Spanish clergyman Santiago López Hernández (born 1957), Mexican politician Santiago López Valdivielso (1950–2024), Spanish politician and businessman Santiago López-Vázquez (born 1971), Spanish competitive sailor