Spica has been borne by at least four ships of the Italian Navy and may refer to:
, a launched in 1905 and discarded in 1923. , a launched in 1934. Sold to Sweden in 1940 and renamed HSwMS Romulus. Decommissioned in 1958. , an captured before launch by Germany in 1943. She was renamed TA45 and launched in 1944. Sunk in 1945. , a launched in 1989.