Susini is a surname. Notable people with the surname include:
Annick de Susini (born 1960), French swimmer Clemente Susini (1754–1814), Italian sculptor Enrique Telémaco Susini (1891-1972), Argentine media entrepreneur Giovanni Francesco Susini (c.1585 – c. 1653), Italian sculptor Jean-Jacques Susini (1933–2017), French political figure Laurent Susini (born 1965), French molecular biologist Telémaco Susini (1856–1936), Argentinian physician