Luke Lea may refer to:
Luke Lea (American politician, born 1783), U.S. Representative from Tennessee, 1833–1837 Luke Lea (American politician, born 1810), Mississippi gubernatorial candidate in 1849, Commissioner of Indian Affairs, U.S. Attorney in Mississippi Luke Lea (American politician, born 1879), U.S. Senator from Tennessee, 1911–1917; founder of The Tennessean newspaper