Waymouth is a surname. Notable people with the surname include:
Edward Waymouth Reid (1862–1948), British physiologist Henry Waymouth (1791–1848), one of the British founding directors of the South Australian Company in 1835 Louis Waymouth (born 1978), British writer and actor Nigel Waymouth (born 1941), American designer and artist Robert Waymouth (born 1960), American chemist