John Giles or Gyles may refer to:
Politicians John Gyles (MP) (died c. 1406), MP for Dover John Giles (MP fl. 1417–1435), MP for Old Sarum, Marlborough, Calne, Wilton and Devizes John Giles (died 1553), MP for Totnes John Giles (died 1606) (c. 1533–1606), MP for Totnes John Godkin Giles (1834–1903), Ontario medical doctor and political figure John Giles (mayor) (born 1960), American mayor of Mesa, Arizona
Others
John Gyles (c. 1680–1755), American soldier and interpreter of American-Indian dialects John Allen Giles (1808–1884), English historian John Giles (priest) (1812–1867), Archdeacon of Stow from 1862 to 1867 John Giles (architect) (1831–1900), British architect John K. Giles (1895–1979), American criminal John Laurent Giles (1901–1969), naval architect John Giles (athlete) (1927–2024), British athlete Johnny Giles (Michael John Giles; born 1940), Irish footballer, manager and television pundit John Giles (snooker player) (born 1969), English snooker player