John Isner defeated Alexander Zverev in the final, 6–7(4–7), 6–4, 6–4 to win the men's singles tennis title at the 2018 Miami Open. It was Isner's first and only Masters 1000 title, and he became the first new Miami Open champion in nine years.
Roger Federer was the defending champion, but lost in the second round to Thanasi Kokkinakis.
Federer and Rafael Nadal (despite having withdrawn from the event) were in contention for the ATP No. 1 singles ranking. Nadal regained the top ranking as a result of Federer's second-round loss.
With Novak Djokovic and Federer losing their opening matches and Andy Murray and Nadal missing the tournament due to injuries, this was the first time since the 2004 Paris Masters that none of the Big Four won a match at a Masters 1000 tournament.
Seeds All seeds receive a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Section 3
Section 4
Bottom half
Section 5
Section 6
Section 7
Section 8
Qualifying
Seeds
Qualifiers
Lucky loser
Qualifying draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
Eighth qualifier
Ninth qualifier
Tenth qualifier
Eleventh qualifier
Twelfth qualifier
References
External links Main draw Qualifying draw