Masayasu is both a given name and a surname. Notable people with the name include:
Hotta Masayasu (1848–1911), Japanese politician Inaba Masayasu (1640–1684), Japanese feudal lord Masayasu Wakabayashi (born 1978), Japanese comedian, television presenter, and actor Masayasu Nomura (1927-2011), Japanese molecular biologist Sogō Masayasu (1562-1587), Japanese samurai