Coiled-coil domain-containing protein 181 (CCDC181) is a protein that in human is encoded by C1orf114, which is located at the Chromosome 1 at 1q24.2. The accession is Q5T1D7. Researches have recently revealed that CCDC 181 is a microtubule-binding protein that interacts with murine Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia. The disruption of Hook1 may lead to inappropriate function of spermatogenesis. The dysfunction may be related to the abnormal head shape of sperm or distinctive structural changes in flagella in sperm, which can result in male infertility. An increased rate of my gene has found in the haploid phase of male cell during meiosis, thus it is believed to relate to sperm cell and aid in spermatogenesis.
Expression
It is discovered that a significant high expression of CCDC 181 found on human testis, which is a male reproductive gland. This is related to the study of its encoded protein-CCDC181, which relates to human infertility when in low expression. Also, high expression of protein is found in the olfactory area and cortical subplate. Researchers have studied the expression of CCDC 181 under different conditions. One of the outstanding findings is that under the coexistence of Rho GTP dissociation inhibitor, the expression of CCDC 181 is depressed. Rho GTP dissociation inhibitor has a phenomenal effect on bladder cancer cells, so studies have suggested that CCDC 181 might also be related to bladder cancer.
Homology
Orthologs have been found mainly in eukaryotes, including mammals, birds, reptiles, amphibians and fishes, with the highest identity on the mammalian species. GenusspeciesCommonnameDivergencefromhumans(MYA)NCBImRNAaccessionSequenceidentitySequence similarityLength(aa)Homo sapiensHumans--NM_001300968----508Odobenus rosmarus divergensWalrus96XP_01242086086%93%507Physeter catodonSperm whale96XP_00710211284%91%509Balaenoptera acutorostrata scammoniMinke whale96XP_00717254884%90%509Ictidomys tridecemlineatusThirteen-lined ground squirrel90XP_02157835481%90%507Octodon degusDegu90XP_02356440880%89%537Rousettus aegyptiacusEgyptian fruit bat96XP_01600409278%88%505Pteropus vampyrusLarge flying fox96XP_02339332978%89%522Condylura cristatastar-nosed mole96XP_00468852278%87%508Mustela putorius furoFerret96XP_00475671569%78%459Nestor notabilisKea312XP_01001406656%72%498Pelodiscus sinensisChinese softshell turtle312XP_00611227555%73%512Sorex araneusshrew96XP_01278933455%71%502Chelonia mydasGreen sea turtle312XP_00706169254%72%517Xenopus tropicaliswestern clawed frog352XP_01281311642%61%471Lonchura striata domesticasociety finch312XP_02140455740%61%488Nanorana parkeriHigh Himalaya frog352XP_01842329136%56%334Scleropages formosusAsian arowana435XP_01860355735%55%389Hippocampus comesTiger tail seahorse435XP_01973571229%44%439