Gregorini () is an Italian surname, derived from the name Gregorio. The Grégorini variant is the French rendering of the original Italian surname.
Notable people with this surname include: Damien Grégorini (born 1979), French football player Francesca Gregorini (born 1968), Italian-American director Giorgio Gregorini, Italian makeup artist Loretta Gregorini (born 1948), Italian astronomer Silvia Gregorini (born 1983), Italian rhythmic gymnast
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