The Pikeville Commercial Historic District in Pikeville, Kentucky, located at Main St. and Division Ave., is a historic district which was listed on the National Register of Historic Places in 1984. It included 10 contributing buildings and 12 non-contributing buildings.

It includes the four-story Pikeville Drug/Anthony Hotel building, built between 1920 and 1925. Includes Kentucky Historic Resources Inventory: Anthony Hotel, by Helen Powell, 1983. With .

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