The 1921 Chico State Wildcats football team represented Chico State Teachers College—now known as California State University, Chico—as an independent during the 1921 college football season. They became a charter member of the California Coast Conference (CCC) in 1922. Led by first-year head coach George Sperry, Chico State compiled a record of 4–3–1. The team played home games at College Field in Chico, California.
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