Nikiema is a surname of Burkinabé origin. Notable people with the surname include:
Abdoul-Aziz Nikiema (born 1985), Burkinabé footballer Elisabeth Nikiema (born 1982), Burkinabé swimmer Issa Nikiema (born 1978), Burkinabé footballer Kadidia Nikiema, Burkinabé Paralympic cyclist Kilian Nikiema (born 2003), Burkinabé footballer Stéphane Nikiéma (born 1965), French kickboxer Victor Nikiema (born 1993), Burkinabé footballer