Picazo is a Spanish surname. Notable people with the surname include:
Axel Picazo (born 2001), Mexican-American footballer Ángel Picazo (1917–1998), Spanish actor Carmen Picazo (born 1975), Spanish lawyer and politician Miguel Picazo (1927–2016), Spanish film director, screenwriter and actor
See also El Picazo, a municipality in Cuenca, Castile-La Mancha, Spain