Piccirillo is an Italian surname. Notable people with the surname include:
Angel Piccirillo (born 1994), American middle-distance runner Hervé Piccirillo (born 1967), French football referee Lisa Piccirillo (born 1991), American mathematician Michele Piccirillo (born 1970), Italian boxer Michele Piccirillo (archaeologist) (1944–2008), Franciscan priest and expert in Byzantine archaeology Mike Piccirillo (born 1951), American musician
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