The 2018 Arizona Diamondbacks season was the franchise's 20th season in Major League Baseball and their 20th season at Chase Field in Phoenix, Arizona as members of the National League West. They were managed by Torey Lovullo in his second season with the Diamondbacks.

The Diamondbacks began the regular season on March 29 against the Colorado Rockies and finished the season on September 30 against the San Diego Padres. The D-backs were in first place in the National League West on April 1, May 1, July 1, August 1 and September 1, but missed the playoffs after a September collapse.

The Diamondbacks started the season with nine consecutive series wins, the first National League team to do so since the 1907 Cubs. On July 7, the D-backs broke the franchise record for runs scored in a single game when they beat the Padres 20–5.

Offseason Transactions October 18, 2017Announced chief baseball analyst Tony La Russa is leaving the organization.October 26, 2017Promoted Jerry Narron to bench coach and Ken Crenshaw to director of sports medicine, performance. Named Luis Urueta coach and did not renew the contract of Ariel Prieto as coach and interpreter.November 6, 2017Exercised the 2018 option on INF Daniel Descalso.November 30, 2017Traded RHP Curtis Taylor to Tampa Bay for RHP Brad Boxberger.December 1, 2017Failed to tender contract offer to RHP J.J. Hoover and LHP T.J. McFarland.December 9, 2017Claimed LHP Henry Owens off waivers from Boston.February 21, 2018Traded INF Brandon Drury to New York Yankees and LHP Anthony Banda and two PTBNL to Tampa Bay. Received RHP Taylor Widener from New York and OF Steven Souza Jr. from Tampa Bay Source

Regular season In 2018, the Diamondbacks introduced a bullpen car, making them the first MLB team to use one since the Milwaukee Brewers in 1995.

Game log

|- align="center" bgcolor=ccffcc | 1 || March 29 || Rockies ||8–2 || Corbin (1–0) || Gray (0–1) || || 48,703 || 1–0 || W1 |- align="center" bgcolor=ccffcc | 2 || March 30 || Rockies ||9–8|| Ray (1–0) || Senzatela (0–1) || Boxberger (1) || 23,937 || 2–0 || W2 |- align="center" bgcolor=ffcccc | 3 || March 31 || Rockies ||1–2|| Shaw (1–0) || Salas (0–1) || Davis (1) || 33,346 || 2–1 || L1 |- align="center" bgcolor=ccffcc | 4 || April 2 || Dodgers ||8–7 (15) || Salas (1–1) || Font (0–1) || — || 21,735 || 3–1 || W1 |- align="center" bgcolor=ccffcc | 5 || April 3 || Dodgers ||6–1|| Godley (1–0) || Kershaw (0–2) || — || 27,574 || 4–1 || W2 |- align="center" bgcolor=ccffcc | 6 || April 4 || Dodgers ||3–0|| Corbin (2–0) || Wood (0–1) || Boxberger (2) || 25,754 || 5–1 || W3 |- align="center" bgcolor=ccffcc | 7 || April 5 || @ Cardinals || 3–1 || Ray (2–0) || Wainwright (0–1) || Boxberger (3) || 46,512 || 6–1 || W4 |- align="center" bgcolor=ffcccc | 8 || April 7 || @ Cardinals || 3–5 || Wacha (1–1) || Greinke (0–1) || Norris (1) || 41,113 || 6–2 || L1 |- align="center" bgcolor=ccffcc | 9 || April 8 || @ Cardinals || 4–1 || Hirano (1–0) || Leone (0–2) || Boxberger (4) || 40,468 || 7–2 || W1 |- align="center" bgcolor=ccffcc | 10 || April 9 || @ Giants || 2–1 || Godley (2–0) || Holland (0–2) || Bradley (1) || 36,997 || 8–2 || W2 |- align="center" bgcolor=ffcccc | 11 || April 10 || @ Giants || 4–5 || Strickland (1–0) || de la Rosa (0–1) || — || 37,869 || 8–3 || L1 |- align="center" bgcolor=ccffcc | 12 || April 11 || @ Giants || 7–3 || Salas (2–1) || Suarez (0–1) || — || 35,041 || 9–3 || W1 |- align="center" bgcolor=ccffcc | 13 || April 13 || @ Dodgers || 8–7 || Greinke (1–1) || Maeda (1–1) || Boxberger (5) || 43,791 || 10–3 || W2 |- align="center" bgcolor=ccffcc | 14 || April 14 || @ Dodgers || 9–1 || McFarland (1–0) || Hill (1–1) || — || 44,306 || 11–3 || W3 |- align="center" bgcolor=ffcccc | 15 || April 15 || @ Dodgers || 2–7 || Kershaw (1–2) || Godley (2–1) || — || 47,527 || 11–4 || L1 |- align="center" bgcolor=ccffcc | 16 || April 17 || Giants || 1–0 || Corbin (3–0) || Watson (1–1) || — || 19,669 || 12–4 || W1 |- align="center" bgcolor=ffcccc | 17 || April 18 || Giants || 3–4 (10) || Strickland (2–0) || Boxberger (0–1) || Gearrin (1) || 16,976 || 12–5 || L1 |- align="center" bgcolor=ccffcc | 18 || April 19 || Giants || 3–1 || Greinke (2–1) || Blach (1–3) || Boxberger (6) || 18,736 || 13–5 || W1 |- align="center" bgcolor=ffcccc | 19 || April 20 || Padres || 1–4 || Hand (1–2) || Boxberger (0–2) || — || 24,902 || 13–6 || L1 |- align="center" bgcolor=ccffcc | 20 || April 21 || Padres || 6–2 || Godley (3–1) || Richard (1–2) || — || 38,820 || 14–6 || W1 |- align="center" bgcolor=ccffcc | 21 || April 22 || Padres || 4–2 || Corbin (4–0) || Lucchesi (2–1) || Bradley (2) || 31,061 || 15–6 || W2 |- align="center" bgcolor=ccffcc | 22 || April 24 || @ Phillies || 8–4 || Salas (3–1) || Velasquez (1–3) || — || 18,195 || 16–6 || W3 |- align="center" bgcolor=ffcccc | 23 || April 25 || @ Phillies || 3–5 || Arrieta (3–0) || Greinke (2–2) || Neris (5) || 21,349 || 16–7 || L1 |- align="center" bgcolor=ccffcc | 24 || April 26 || @ Phillies || 8–2 || Koch (1–0) || Lively (0–2) || — || 20,335 || 17–7 || W1 |- align="center" bgcolor=ccffcc | 25 || April 27 || @ Nationals || 5–4 || Godley (4–1) || Strasburg (2–3) || Boxberger (7) || 26,517 || 18–7 || W2 |- align="center" bgcolor=ccffcc | 26 || April 28 || @ Nationals || 4–3 (10) || Hirano (2–0) || Solis (0–1) || Boxberger (8) || 32,963 || 19–7 || W3 |- align="center" bgcolor=ffcccc | 27 || April 29 || @ Nationals || 1–3 || González (3–2) || McFarland (1–1) || Doolittle (5) || 30,285 || 19–8 || L1 |- align="center" bgcolor=ccffcc | 28 || April 30 || Dodgers || 8–5 || Greinke (3–2) || Stripling (0–1) || Boxberger (9) || 17,562 || 20–8 || W1

|- align="center" bgcolor=ccffcc | 29 || May 1 || Dodgers || 4–3 || Bracho (1–0) || Liberatore (1–1) || Boxberger (10) || 18,940 || 21–8 || W2 |- align="center" bgcolor=ffcccc | 30 || May 2 || Dodgers || 1–2 || Hudson (1–0) || Godley (4–2) || Jansen (4) || 19,531 || 21–9 || L1 |- align="center" bgcolor=ffcccc | 31 || May 3 || Dodgers || 2–5 || Chargois (1–0) || Salas (3–2) || Jansen (5) || 21,407 || 21–10 || L2 |- align="center" bgcolor=ffcccc | 32 || May 4 || Astros || 0–8 || Cole (3–1) || Medlen (0–1) || — || 29,463 || 21–11 || L3 |- align="center" bgcolor=ccffcc | 33 || May 5 || Astros || 4–3 || Boxberger (1–2) || Devenski (1–1) || — || 39,154 || 22–11 || W1 |- align="center" bgcolor=ccffcc | 34 || May 6 || Astros || 3–1 || Koch (2–0) || Verlander (4–1) || Boxberger (11) || 35,632 || 23–11 || W2 |- align="center" bgcolor=ccffcc | 35 || May 8 || @ Dodgers || 8–5 (12) || McFarland (2–1) || García (0–1) || — || 45,894 || 24–11 || W3 |- align="center" bgcolor=ffcccc | 36 || May 9 || @ Dodgers || 3–6 || Báez (1–1) || Salas (3–3) || Jansen (6) || 45,600 || 24–12 || L1 |- align="center" bgcolor=ffcccc | 37 || May 10 || Nationals || 1–2 (11) || Kintzler (1–2) || Salas (3–4) || Doolittle (7) || 17,397 || 24–13 || L2 |- align="center" bgcolor=ffcccc | 38 || May 11 || Nationals || 1–3 || Scherzer (7–1) || Koch (2–1) || Doolittle (8) || 22,901 || 24–14 || L3 |- align="center" bgcolor=ffcccc | 39 || May 12 || Nationals || 1–2 || Strasburg (5–3) || Scribner (0–1) || Madson (3) || 29,428 || 24–15 || L4 |- align="center" bgcolor=ffcccc | 40 || May 13 || Nationals || 4–6 || Madson (1–2) || Bradley (0–1) || Doolittle (9) || 31,906 || 24–16 || L5 |- align="center" bgcolor=ffcccc | 41 || May 14 || Brewers || 2–7 || Guerra (3–3) || Corbin (4–1) || — || 17,390 || 24–17 || L6 |- align="center" bgcolor=ccffcc | 42 || May 15 || Brewers || 2–1 || Bradley (1–1) || Williams (0–1) || Boxberger (12) || 17,914 || 25–17 || W1 |- align="center" bgcolor=ffcccc | 43 || May 16 || Brewers || 2–8 || Woodruff (2–0) || Koch (2–2) || — || 16,762 || 25–18 || L1 |- align="center" bgcolor=ffcccc | 44 || May 18 || @ Mets || 1–3 || deGrom (4–0) ||Godley (4–3) || Familia (12) || 31,285 || 25–19 || L2 |- align="center" bgcolor=ffcccc | 45 || May 19 || @ Mets || 4–5 ||Familia (2–1) || Chafin (0–1) || — || 39,515 || 25–20 || L3 |- align="center" bgcolor=ffcccc | 46 || May 20 || @ Mets || 1–4 || Syndergaard (4–1) || de la Rosa (0–2) || Gsellman (1) || 34,894 || 25–21 || L4 |- align="center" bgcolor=ffcccc | 47 || May 21 || @ Brewers || 2–4 || Anderson (4–3) || Greinke (3–3) || Knebel (2) || 27,094 || 25–22 || L5 |- align="center" bgcolor=ffcccc | 48 || May 22 || @ Brewers || 0–1 || Albers (3–1) || Koch (2–3) || Knebel (3) || 27,065 || 25–23 || L6 |- align="center" bgcolor=ffcccc | 49 || May 23 || @ Brewers || 2–9 || Suter (4–3) || Godley (4–4) || — || 29,237 || 25–24 || L7 |- align="center" bgcolor=ccffcc | 50 || May 25 || @ A's || 7–1 || Corbin (5–1) || Manaea (5–5) || — || 22,691 || 26–24 || W1 |- align="center" bgcolor=ffcccc | 51 || May 26 || @ A's || 0–3 || Mengden (5–4) || Buchholz (0–1) || — || 17,580 || 26–25 || L1 |- align="center" bgcolor=ffcccc | 52 || May 27 || @ A's || 1–2 || Montas (1–0) || Greinke (3–4) || Treinen (12) || 13,947 || 26–26 || L2 |- align="center" bgcolor=ccffcc | 53 || May 28 || Reds || 12–5 || Koch (3–3) || Bailey (1–7) || — || 29,924 || 27–26 || W1 |- align="center" bgcolor=ccffcc | 54 || May 29 || Reds || 5–2 || Godley (5–4) || Castillo (4–5) || Boxberger (13) || 20,046 || 28–26 || W2 |- align="center" bgcolor=ffcccc | 55 || May 30 || Reds || 4–7 || Romano (3–6) || Corbin (5–2) || Iglesias (9) || 18,340 || 28–27 || L1

|- align="center" bgcolor=ccffcc | 56 || June 1 || Marlins || 9–1 || Buchholz (1–1) || Hernandez (0–3) || — || 25,866 || 29–27 || W1 |- align="center" bgcolor=ccffcc | 57 || June 2 || Marlins || 6–2 || Greinke (4–4) || Smith (4–6) || — || 34,117 || 30–27 || W2 |- align="center" bgcolor=ccffcc | 58 || June 3 || Marlins || 6–1 || Koch (4–3) || Straily (2–2) || — || 31,727 || 31–27 || W3 |- align="center" bgcolor=ffcccc | 59 || June 4 || @ Giants || 3–10 || Johnson (3–2) || Godley (5–5) || — || 36,542 || 31–28 || L1 |- align="center" bgcolor=ccffcc | 60 || June 5 || @ Giants || 3–2 || Corbin (6–2) || Bumgarner (0–1) || Boxberger (14) || 36,925 || 32–28 || W1 |- align="center" bgcolor=ffcccc | 61 || June 6 || @ Giants || 4–5 (10) || Strickland (3–2) || Chafin (0–2) || — || 41,042 || 32–29 || L1 |- align="center" bgcolor=ccffcc | 62 || June 8 || @ Rockies || 9–4 || Greinke (5–4) || Márquez (4–6) || — || 38,917 || 33–29 || W1 |- align="center" bgcolor=ccffcc | 63 || June 9 || @ Rockies || 12–7 || Bracho (2–0) || Shaw (2–5) || — || 43,197 || 34–29 || W2 |- align="center" bgcolor=ccffcc | 64 || June 10 || @ Rockies || 8–3 || Godley (6–5) || Freeland (6–6) || — || 36,433 || 35–29 || W3 |- align="center" bgcolor=ccffcc | 65 || June 11 || Pirates || 9–5 || Bradley (2–1) || Crick (0–1) || — || 20,927 || 36–29 || W4 |- align="center" bgcolor=ccffcc | 66 || June 12 || Pirates || 13–8 || Salas (4–4) || Williams (5–4) || — || 22,488 || 37–29 || W5 |- align="center" bgcolor=ffcccc | 67 || June 13 || Pirates || 4–5 || Taillon (4–5) || Greinke (5–5) || Vázquez (12) || 32,803 || 37–30 || L1 |- align="center" bgcolor=ccffcc | 68 || June 14 || Mets || 6–3 || Koch (5–3) || Vargas (2–5) || Boxberger (15) || 23,300 || 38–30 || W1 |- align="center" bgcolor=ccffcc | 69 || June 15 || Mets || 7–3 || Godley (7–5) || Lugo (2–2) || Boxberger (16) || 32,170 || 39–30 || W2 |- align="center" bgcolor=ffcccc | 70 || June 16 || Mets || 1–5 || Matz (3–4) || Corbin (6–3) || — || 31,824 || 39–31 || L1 |- align="center" bgcolor=ffcccc | 71 || June 17 || Mets || 3–5 || Familia (3–3) || Boxberger (1–3) || Gsellman (3) || 47,907 || 39–32 || L2 |- align="center" bgcolor=ccffcc | 72 || June 18 || @ Angels || 7–4 || Greinke (6–5) || Barria (5–3) || Bradley (3) || 33,809 || 40–32 || W1 |- align="center" bgcolor=ffcccc | 73 || June 19 || @ Angels || 4–5 || Álvarez (3–2) || Koch (5–4) || Parker (8) || 33,088 || 40–33 || L1 |- align="center" bgcolor=ccffcc | 74 || June 21 || @ Pirates || 9–3 || Godley (8–5) || Kuhl (5–5) || — || 20,554 || 41–33 || W1 |- align="center" bgcolor=ccffcc