Cannone is an Italian surname. Notable people with the surname include:
Cosimo Aldo Cannone (born 1984), Italian motorboat racer Domenico Cannone (born 1973), Italian sprint canoeist Flavio Cannone (born 1981), Italian trampolinist Giuseppe Cannone (born c. 1924), Italian rugby league player Patrick Cannone (born 1986), American ice hockey player Romain Cannone (born 1997), French fencer