Bonini is an Italian surname. Notable people with the surname include:
Alexander Bonini (c. 1270 – 1314), Italian Franciscan philosopher Antonio Bonini (born 1954), Italian volleyball player Arturo José Bonini (1943–2022), Argentine actor better known as Arturo Bonín Colin Bonini (born 1965), American politician Francesco Maria Bonini (1865–1930), Italian opera singer Giovanni Bonini, 14th-century Italian painter Giovanni Bonini (footballer) (born 1986), Sammarinese footballer Giuseppe Bonini, Italian middle-distance runner Girolamo Bonini (died 1680), Italian Baroque painter Massimo Bonini (born 1959), Sammarinese footballer and manager Nancy Bonini (born 1959), American neuroscientist and geneticist Oscar Bonini (born 1959), Argentine rower Severo Bonini (1582–1663), Italian classical composer, organist and music theorist