Gillem is a surname. Notable people with the surname include:
Alvan Cullem Gillem (1830–1875), Union Army officer Alvan Cullem Gillem II (1917–2009), United States Air Force general Alvan Cullom Gillem Jr. (1888–1973), United States Army general Gladys Gillem (1920–2009), American professional wrestler Jenks Gillem (c. 1890 – 1951), American football player and coach
See also Fort Gillem, a former United States Army post in Forest Park, Georgia