Greathouse is an English surname. Notable people with the surname include:
Clarence Ridgley Greathouse (1846–1899), American lawyer, journalist and diplomat Daniel Greathouse (c.1752 – 1775), American pioneer Ed Greathouse (1899–1954), American boxer Jaden Greathouse (born 2004), American football player Shiloh Greathouse, American skateboarder William M. Greathouse (1919–2011), American Nazarene minister and theologian