Kilduff is a surname. Notable people with the surname include:
Christine Kilduff, American politician Ciarán Kilduff (born 1988), Irish footballer Malcolm Kilduff (1927–2003), American journalist Marshall Kilduff (born 1949), American journalist Martin Kilduff, British academic Mitchell Kilduff (born 1996), Australian swimmer Pete Kilduff (1893–1930), American baseball player Thomas Kilduff, American neuroscientist Vinnie Kilduff (born 1960), Irish folk artist