Sethupathi is an Indian surname that may refer to Indian royalty
Sethupathi, rulers of Ramnad Muthuramalinga Sethupathi II (1841–1873) Raja Rajeswara Sethupathi (1889–1929) Ramanatha Sethupathi (died 1979) Vijayaraghunatha Sethupathi (died 1720) Raghunatha Kilavan Bhaskara Sethupathi
Others Rajkumar Sethupathi, Indian actor Shanmugha Rajeswara Sethupathi (1909–1967), Indian politician Vijay Sethupathi (born 1978), Indian film actor, producer, lyricist, and dialogue writer Latha (actress) or Latha Sethupathi, Indian actress, sister of Rajkumar Sethupathi