The canton of Les Coteaux de Guyenne is an administrative division of the Lot-et-Garonne department, southwestern France. It was created at the French canton reorganisation which came into effect in March 2015. Its seat is in Duras.

It consists of the following communes:

Agmé Auriac-sur-Dropt Baleyssagues Cambes Castelnau-sur-Gupie Caubon-Saint-Sauveur Duras Escassefort Esclottes Jusix Lachapelle Lagupie Lévignac-de-Guyenne Loubès-Bernac Mauvezin-sur-Gupie Monteton Montignac-Toupinerie Moustier Pardaillan Puymiclan Saint-Astier Saint-Avit Saint-Barthélemy-d'Agenais Sainte-Colombe-de-Duras Saint-Géraud Saint-Jean-de-Duras Saint-Martin-Petit Saint-Pierre-sur-Dropt Saint-Sernin La Sauvetat-du-Dropt Savignac-de-Duras Seyches Soumensac Villeneuve-de-Duras

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