Siragusa is a surname. Notable people with the surname include:
Charles J. Siragusa (born 1947), American judge Charles Siragusa (born 1913), American federal narcotics agent Elisa Siragusa (born 1986), Italian politician Irene Siragusa (born 1993), Italian sprinter Kaitlyn Siragusa or Amouranth (born 1993), American cosplayer and streamer Nico Siragusa (born 1994), American football player Stefano Siragusa (born 1976), Italian businessman Tony Siragusa (1967–2022), American football player