Knüpfer is a surname. Notable people with the name include:
Johann Knüpfer (1866–1910), schizophrenic outsider artist Kerstin Knüpfer (born 1963), German handball player Nikolaus Knüpfer (1609–1655), Dutch Golden Age painter Sebastian Knüpfer (1633–1676), German composer, conductor and educator
See also Edy Knupfer (1912 –1979), Swiss architect