The canton of Vallée de l'Isle is an administrative division of the Dordogne department, southwestern France. It was created at the French canton reorganisation which came into effect in March 2015. Its seat is in Neuvic.

It consists of the following communes:

Beaupouyet Beauronne Bourgnac Chantérac Douzillac Les Lèches Mussidan Neuvic Saint-Aquilin Saint-Étienne-de-Puycorbier Saint-Front-de-Pradoux Saint-Germain-du-Salembre Saint-Jean-d'Ataux Saint-Laurent-des-Hommes Saint-Louis-en-l'Isle Saint-Martin-l'Astier Saint-Médard-de-Mussidan Saint-Michel-de-Double Saint-Séverin-d'Estissac Sourzac Vallereuil

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