The canton of Saint-Lô-1 is an administrative division of the Manche department, northwestern France. It was created at the French canton reorganisation which came into effect in March 2015. Its seat is in Saint-Lô.

It consists of the following communes:

Agneaux Le Lorey Marigny-le-Lozon Le Mesnil-Amey Le Mesnil-Eury Montreuil-sur-Lozon Remilly-les-Marais Saint-Gilles Saint-Lô (partly) Thèreval

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