Masondo is a South African surname. Notable people with the surname include:
Amos Masondo (born 1953), South African politician Andrew Masondo (1936–2008), South African activist David Masondo (born 1974), South African politician David Masondo (singer) (1950–2015), was South African singer and drummer Sizwe Masondo (born 1987), South African cricketer Thabile Masondo, South African politician Vusumuzi Masondo (born 1957), South African military commander