Manetti is an Italian surname. Notable people with the surname include:
Antonio Manetti (1423–1497), Italian mathematician and architect Domenico Manetti (1609–1663), Italian painter Giannozzo Manetti (1396–1459), Italian politician and diplomat Larry Manetti (born 1947), American actor Ricardo Mannetti (born 1975), Namibian footballer Rutilio di Lorenzo Manetti, (c. 1571 – 1639), Italian painter Saverio Manetti (1723–1785), Italian physician, botanist and ornithologist Teresa Maria Manetti, (1846–1910), Italian Roman Catholic nun