Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12), is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol.
Gene and Transcript In the DNA, C6orf62 is 12,529 base pairs long and is located at 6q22.3. It is located on chromosome 6 on position 22.3 (6q22.3). The mature mRNA sequence is 2498 base-pairs long with 5 exons and 4 intronic regions that translates a protein that is 229 amino acids long and two predicted isoforms of 160 amino acids and 200 amino acids.
Protein The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a domain of unknown function (DUF4566) present in all three variants and spans positions 1–226 on the main transcript. The molecular weight of C6orf62 is 27.1 kDa and its isoelectric point is at a pH of 9.24. It is located subcellularly localized throughout the cytosol.
Protein Interactions
ProteinELAVL1predicted through affinity capture-RNA.PVRL4predicted through affinity capture-mass spectroscopy.NADHpredicted through yeast two-hybrid screening.
Expression C6orf62 is broadly expressed within the human body, however, its protein abundance is not high. It is more heavily expressed in the gallbladder and testis, but it is not predicted to be expressed in the smooth muscle, lymph nodes, the spleen, ovaries, adipose tissue, and soft tissue.
Homology C6orf62 is highly conserved among vertebrates and has orthologs found in invertebrates.
Orthologs in Select Mammals
Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % SimilarityPongoabeliiSumatran Orangutan15.2NP_001126883.12329999IctidomystridecemlineatusGround Squirrel88XP_005337081.12319998TupaiachinensisTreeshrew85XP_006162754.12678498RattusnorvegicusBrown Rat88NP_001017510.12329998
Orthologs in Select Ray-Finned Fish
Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % SimilaritySalmosalarSalmon435XP_014034327.12338293SinocyclocheilusrhinocerosGolden-lined Barbell435XP_016388718.12308794HippocampuscomesSeahorse435XP_019729847.12348091
Orthologs in Select Amphibians
Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % SimilarityNanoranaparkeriHigh Himalaya Frog353XP_018411819.12329597XenopustrpocalisAfrican Clawed Frog353NP_001120278.12329398
Orthologs in Select Reptiles
Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % SimilarityChrysemyspicta belliPainted Turtle320XP_005281462.12339798PythonvbivittatusBurmese Python320XP_007521998.12339699CheloniamydasGreen Sea Turtle320XP_007060449.12319798AlligatorsinensisChinese Alligator320XP_006034488.12329899
Orthologs in Select Birds
Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % SimilarityTauracoerythrolophusRed-crested Tauraco320XP_009991398.123297TaeniopygiaguttataZebra Finch320XP_002194166.123298ManacusvitellinusGold Marked Manakin320XP_017925511.124198 Orthologs in Select Invertebrates Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % SimilarityCionaintestinalisSea Squirt677XP_002119736.12333862CrassostreagigasPacific Oyster758XP_011438527.12316280HellobdellarobustaGlossiphoniidae Leech758XP_009016977.12643551OctopusbimaculoidesTwo-Spot Octopus758XP_014780369.11976079SaccoglossuskowalevskiiAcorn Worm627XP_002741666.12306683
References