This is a list of cytochrome P450 modulators, or inhibitors and inducers of cytochrome P450 enzymes.
Enzyme Inhibitors Inducers CYP1A1 Certain foods (e.g., cumin, turmeric) Certain herbs/herbal teas (e.g., peppermint, German chamomile, dandelion, Kava) Amiodarone Caffeine Cimetidine Citalopram Crisaborole Echinacea Efavirenz Fluoroquinolones (e.g., ciprofloxacin) Fluvoxamine Interferon Isoniazid Methoxsalen Mibefradil Naringenin (grapefruit) Nilutamide Ribociclib Rucaparib Simeprevir St. John's wort Ticlopidine Verapamil Certain foods (e.g., broccoli, cauliflower, brussels sprouts, chargrilled meat) Armodafinil Insulin Methylcholanthrene Modafinil Nafcillin Omeprazole Phenytoin beta-Naphthoflavone Tobacco CYP2A6 Amiodarone Amlodipine Buprenorphine Clofibrate Clotrimazole Desipramine Disulfiram Entacapone Fenofibrate Flavonoids (grapefruit) Gabapentin Isoniazid Ketoconazole Letrozole Methimazole Methoxsalen Metyrapone Miconazole Modafinil Nicotine Orphenadrine Pilocarpine Pregabalin Selegiline Sulconazole Tioconazole Tranylcypromine Barbiturates (e.g., amobarbital, pentobarbital, phenobarbital, secobarbital) Rifampicin CYP2B6 Clopidogrel Crisaborole Curcumin (turmeric) Memantine Orphenadrine Rucaparib Thiotepa Ticlopidine Voriconazole Withania somnifera (Ashwagandha) Carbamazepine Phenobarbital Phenytoin Rifampicin CYP2C8 Gemfibrozil Letermovir Montelukast Perampanel Quercetin Teriflunomide Thiazolidinediones Trimethoprim Rifampicin Rifapentine CYP2C9 Amiodarone Apigenin Chloramphenicol Cimetidine Cyclizine Fenofibrate Flavonoids (e.g., amentoflavone (Ginkgo biloba, St. John’s Wort)) Fluconazole Fluvastatin Fluvoxamine Isoniazid Kava Lovastatin Miconazole Modafinil Nilutamide Paroxetine Phenylbutazone Probenecid Promethazine Quercetin Sertraline Sulfamethoxazole Sulfaphenazole Teniposide Valproic acid Voriconazole Zafirlukast Aprepitant Bosentan Carbamazepine Enzalutamide Phenobarbital Phenytoin Rifampicin Rifapentine Secobarbital St. John's Wort CYP2C19 Armodafinil Cannabidiol Chloramphenicol Cimetidine Citalopram Felbamate Fluconazole Fluoxetine Fluvoxamine Indomethacin Isoniazid JWH-018 Kava Ketoconazole Moclobemide Modafinil Oxcarbazepine Probenecid Proton pump inhibitors (e.g., esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole) Ticlopidine Topiramate Artemisinin Aspirin Carbamazepine Enzalutamide Norethisterone Phenytoin Prednisone Rifampicin CYP2D6 Amiodarone Buprenorphine Bupropion Cannabidiol Celecoxib Chlorphenamine Chlorpromazine Cimetidine Cinacalcet Citalopram Clemastine Clomipramine Cocaine Diphenhydramine Doxepin Doxorubicin Duloxetine Escitalopram Fluoxetine Halofantrine Haloperidol Hydroxyzine Hyperforin (St. John's Wort) Kava Levomepromazine Methadone Methylphenidate Metoclopramide Mibefradil Midodrine Moclobemide Niacin (nicotinic acid) and its form – niacinamide (nicotinamide), collectively called as vitamin B3 Omeprazole Paroxetine Perphenazine Promethazine Quinidine Ranitidine Risperidone Ritonavir Sertraline Terbinafine Thioridazine Ticlopidine Tripelennamine Zuclopenthixol Dexamethasone Glutethimide Haloperidol Rifampicin CYP2E1 Cimetidine Niacin (nicotinic acid) and its form – niacinamide (nicotinamide), collectively called as vitamin B3 Clomethiazole Ethanol (Alcohol (drug)) Isoniazid CYP3A4 Amiodarone Aprepitant Bergamottin (grapefruit) Buprenorphine Cafestol Cannabidiol Chloramphenicol Cimetidine Ciprofloxacin Clarithromycin Cobicistat Colchicine Delavirdine Diltiazem Dithiocarbamate Domperidone Erythromycin Esomeprazole Fluconazole Fluvoxamine Gestodene Ginkgo biloba Imatinib Indinavir Isoniazid Itraconazole Kava Ketoconazole Mibefradil Mifepristone Milk thistle Nefazodone Nelfinavir Niacin (nicotinic acid) and its form – niacinamide (nicotinamide), collectively called as vitamin B3 Nilutamide Norfloxacin Omeprazole Orphenadrine Pantoprazole Piperine Quercetin Ranitidine Ritonavir Saquinavir Seproxetine ((S)-norfluoxetine/ Fluoxetine metabolite) Star fruit Telithromycin Valerian Valproic acid Verapamil Voriconazole Armodafinil Barbiturates (e.g., butalbital, phenobarbital) Capsaicin Carbamazepine Efavirenz Enzalutamide Glucocorticoids Modafinil Nevirapine Oxcarbazepine Phenytoin Pioglitazone Quercetin Rifabutin Rifampicin Rifapentine St. John's wort Topiramate Troglitazone Withania somnifera (Ashwagandha) CYP4–51 See Prostanoid signaling modulators and Leukotriene signaling modulators instead for eicosanoid-specific CYP450s, including: CYP4F3 (leukotriene-B4 ω-hydroxylase 2) CYP5A1 (thromboxane-A synthase) CYP8A1 (prostacyclin synthase) See the list of steroid metabolism modulators instead for steroid/sterol-specific CYP450s, including: CYP7A1 (cholesterol 7α-hydroxylase) CYP7B1 (25-hydroxycholesterol 7α-hydroxylase) CYP8B1 (sterol 12α-hydroxylase) CYP11A1 (cholesterol side-chain cleavage enzyme; P450scc) CYP11B1 (steroid 11β-hydroxylase) CYP11B2 (aldosterone synthase) CYP17A1 (steroid 17α-hydroxylase/17,20-lyase) CYP19A1 (aromatase) CYP21A2 (steroid 21-hydroxylase) CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase) CYP27A1 (sterol 27-hydroxylase) CYP27B1 (25-hydroxyvitamin D3 1α-hydroxylase) CYP39A1 (oxysterol 7α-hydroxylase 2) CYP46A1 (cholesterol 24-hydroxylase) CYP51A1 (lanosterol 14α-demethylase)
See also List of steroid metabolism modulators
Sources Includes information found online including these sites: