The Incredulity of Saint Thomas is a 1543–1547 painting by Francesco Salviati. It was commissioned for the église Notre-Dame-de-Confort in Lyon by Thomas II de Gadagne (also known as Tomaso Guadagni), a Florentine counselor to Francis I of France. It is now held in the Louvre Museum and measures 275 cm by 234 cm. It is signed FRANCESCO SALVIATO FLO. OPUS (S.B.D.) and the apostle shown in three-quarter-profile is a self-portrait of Salviati.Notice du Louvre

Its choice of subject reflects an anti-Medici political viewpoint shared by commissioner and artist.« Arte civica a Firenze, dal primo popolo all'umanesimo: la tradizione, i modelli perduti », in Expo. Florence, 2013, p. 18-33 The work proved popular from its arrival in Lyon onwards and was copied by several artists in several media, including an engraving by Master CC.Bibliothèque nationale de France, Est. Ed 4b rés. fol. Even after art history began to neglect art produced in and for Lyon, the painting was one of few such works still to be mentioned - for example, it appears in Giorgio Vasari's Lives.

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