Rio Xufexufe is a river in the island of São Tomé, São Tomé and Príncipe. The river flows southward through the southern part of the Lembá District and empties into the Atlantic Ocean between the beaches of Palma and Pipa, 10 km northwest of Vila Malanza. Its catchment area is .Recursos e Projectos de Energias Renováveis, Associação Lusófona de Energias Renováveis, p. 6 The endangered birds São Tomé olive pigeon (Columba thomensis) and São Tomé fiscal (Lanius newtoni) have been observed in the catchment of the river.
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