Tofano is an Italian surname. Notable people with the surname include:
Edoardo Tofano (1838–1920), Italian painter Rosetta Tofano (1902–1960), Italian costume designer and film star Sergio Tòfano (1886–1973), Italian actor, director, playwright, scene designer and illustrator Tecla Tofano (1927–1995), Venezuelan artist, ceramicist, and writer