Phythian is an English surname of Roman origin meaning "son of Fithion" or Vivian. Notable people with the surname include:
Charles Phythian-Adams (1937–2025), English local historian Dylan Phythian (born 1995), Australian rugby league footballer Ernie Phythian (1942–2020), English football player Mark Phythian (born 1985), English cricket player Robert L. Phythian (1835–1917), American naval officer
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