Simphiwe is a South African given name. Notable people with the name include:
Simphiwe Dana (born 1980), South African singer-songwriter Simphiwe Dludlu (born 1987), South African football defender Simphiwe Khonco, South African boxer Simphiwe Nongqayi (born 1972), South African boxer Simphiwe Yiba (born 1992), South African cricketer