Luisi is an Italian surname. Notable people with the surname include:
Antonio Luisi (born 1994), Luxembourgish footballer Carlo Luisi (born 1977), Italian footballer Clotilde Luisi (1882–1969), Uruguayan lawyer Fabio Luisi (born 1959), Italian conductor Gianluca Luisi (born 1970), Italian classical pianist Hector Luisi (1919–2013), Uruguayan politician James Luisi (1928–2002), American basketball player and actor Paulina Luisi (1875–1945), Uruguayan feminist Pier Luigi Luisi (born 1938), Italian chemist Zebastian Lucky Luisi (born 1984), New Zealand rugby league player