Physoglenes is a genus of Chilean araneomorph spiders in the family Physoglenidae that was first described by Eugène Louis Simon in 1904. It has been listed under several different families, including Leptonetidae, Pholcidae, Synotaxidae, and most recently, Physoglenidae.
Species it contains four species, found in Chile: Physoglenes chepu Platnick, 1990 – Chile Physoglenes lagos Platnick, 1990 – Chile Physoglenes puyehue Platnick, 1990 – Chile Physoglenes vivesi Simon, 1904 (type) – Chile
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