Course of Empire may refer to:
Art The Course of Empire (paintings), a series of paintings created by Thomas Cole from 1833 to 1836 The Course of Empire, an art exhibit by Edward Ruscha
Literature The Course of Empire (history book), a 1952 American history book by Bernard DeVoto Course of Empire (novel), a 2003 science-fiction novel by Eric Flint and K.D. Wentworth The Course of Empire: The Arabs and Their Successors, a 1966 book by John Bagot Glubb
Music Course of Empire (band), an American alternative/post-punk band Course of Empire (album) The Course of Empire, a 2019 album by Atlantean Kodex
See also Westward the Course of Empire Takes Its Way, an 1861 mural by Emanuel Leutze in the United States Capitol Building