Gobble Hollow is a valley in eastern St. Francois County in the U.S. state of Missouri. It is a tributary to the Little Saint Francois River.
The headwaters of the intermittent stream in the valley are at Womack Missouri, 7.5 Minute Topographic Quadrangle, U.S. Geologic Survey, 1980 and the confluence with the Little Saint Francois is at .Knob Lick, Missouri, 7.5 Minute Topographic Quadrangle, U.S. Geologic Survey, 1959
Gobble Hollow was so named due to the presence of wild turkeys in the valley.
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