Setälä () is a Finnish surname. Notable people with the surname include:
Eemil Nestor Setälä (1864–1935), Finnish politician Jukka Setälä (born 1967), Finnish designer Kai Setälä (1913–2005), Finnish physician and professor Päivi Setälä (1943–2014), Finnish historian and professor Toivo Aalto-Setälä (1896–1977), Finnish lawyer and politician