In principio (Latin "In the beginning") may refer to:
Genesis 1:1: In principio creavit Deus cælum et terram. John 1:1: In principio erat verbum.
Music In principio, for choir and orchestra by Arvo Pärt In principio, chant by Hildegard von Bingen In principio, work for piano by Ludovico Einaudi In principio erat verbum, motet by Josquin Desprez In principio erat verbum, motet by Orlando di Lasso In Principio, track by Dutch trance project Gaia