Anastasiadis is a Greek surname. Notable people with the surname include:

Anestis Anastasiadis (born 1983) Greek footballer Angelos Anastasiadis (born 1953) Greek football manager Dean Anastasiadis (born 1970) Australian football coach, brother of John John Anastasiadis (born 1968) Australian football manager, brother of Dean Nikos Anastasiadis (born 1946) 7th and current (2013-) President of Cyprus Themos Anastasiadis (1958–2019) Greek Journalist