Musco Creek is a stream in Madison and St. Francois counties in the U.S. state of Missouri. It is a tributary of the Little Saint Francis River.Fredericktown, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1980
The stream headwaters arise in St. Francois County north of Knob Lick and it flows generally south passing just west of Knob Lick. It flows roughly parallel to US Route 67 and enters Madison County. It enters the Little Saint Francis about two miles west of Mine La Motte.Knob Lick, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1980
The source area is at and the confluence is at .
Musco was named after a local Indian settler, according to local history.
See also List of rivers of Missouri
References