MI8, MI-8, or another variant may refer to:
AMD's MI8, a brand of deep learning oriented Graphics Processing Units, see Radeon Instinct MI8, the World War II British signals intelligence agency Mil Mi-8, the Soviet-designed helicopter Mitten im 8en, an Austrian TV soap/comedy series Black Chamber, the United States' first peacetime cryptanalytic organization
M-8 (Michigan highway) Xiaomi Mi 8, smartphone developed by Xiaomi Mission: Impossible – The Final Reckoning, a spy-thriller film directed by Christopher McQuarrie and starring Tom Cruise