Mussi is an Italian surname. Notable people with the surname include:
Camillo Mussi (1911–1940), Italian ice hockey player Carolina Mussi (born 1988), Brazilian swimmer Fabio Mussi (born 1948), Italian politician Giuseppe Mussi (1836–1904), Italian politician Juan José Mussi (1941–2025), Argentine politician Mary Mussi, née Edgar (1907–1991), British writer, known as Mary Howard Roberto Mussi (born 1963), Italian footballer
See also Muzzi Musi (disambiguation)