Wagon Knob is a summit in southern Lafayette County in the U.S. state of Missouri. The summit has an elevation of . The feature consists of a linear north-south oriented ridge with two summits. The hill is west of Missouri Route 131 and south of Odessa.Odessa South, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1963

Wagon Knob was named after a wrecked wagon which was left there.

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