The women's 100 metre butterfly S8 event at the 2016 Paralympic Games took place on 9 September 2016, at the Olympic Aquatics Stadium. Two heats were held. The swimmers with the eight fastest times advanced to the final.

Heats Heat 1 11:26 9 September 2016:

Rank Lane Name Nationality Time Notes 1 4 1:11.56 2 5 1:12.29 3 3 1:16.18 4 6 1:18.44 5 2 1:21.29 6 7 1:30.14

Heat 2 11:30 9 September 2016: Rank Lane Name Nationality Time Notes 1 5 1:10.36 2 4 1:16.32 3 6 1:16.94 4 7 1:19.96 5 2 1:21.99 6 1 1:27.78 7 3 1:28.19

Final 20:22 9 September 2016:

Rank Lane Name Nationality Time Notes 4 1:09.04 2 1:10.32 5 1:10.53 4 3 1:11.68 5 7 1:13.52 6 6 1:13.80 7 1 1:17.41 8 8 1:18.99

Notes